Present Position
9/04-Present Postdoctoral Fellow with David Eisenberg, Ph.D. University of California at Los Angeles Bioinformatic and Structural Studies of Domain Swapping, Protein Misfolding Disease, and Protein Networks

Education
Ph.D. Chemistry and Biochemistry University of Colorado at Boulder 2003
Lin Chen, Ph.D.
Structural and Functional Studies of Rel Homology Region Containing Proteins
M.A. Biochemistry and Molecular Biophysics Columbia University, NY, NY 1994
B.S. Molecular Biology University of Texas at Austin 1993

Research Experience
1/04-9/04 Postdoctoral Research Associate with Lin Chen, Ph.D. University of Colorado at Boulder Structural Studies of Transcription Factors Involved in Language and T-Cell Anergy
3/99-12/03 Graduate Student with Lin Chen, Ph.D. University of Colorado at Boulder Structural and Functional Studies of Rel Homology Region Containing Proteins
10/94-8/98 Research Assistant with John McCarrey, Ph.D. Southwest Foundation For Biomedical Research, San Antonio, TX Regulation of Transcription, DNA Methylation, and Chromatin Structure During Gametogenesis

Honors and Awards
Ruth L. Kirschstein Postdoctoral Fellowship NIH 2007
Training Grant for Signal Transduction and Cell Cycle Regulation NIH 2001-2002 AY
Training Grant for Signal Transduction and Cell Cycle Regulation NIH 2000-2001 AY
University Fellowship Recipient University of Colorado 1999
Graduate Fellowship Recipient Colorado Institute for Research in Biotechnology 1999
Presidential Scholar Incarnate Word College, San Antonio, TX 1989-1990 AY
Presidential Scholar Incarnate Word College, San Antonio, TX 1988-1989 AY

Research Articles
Bates DL Barthel KKB Wu Y Kalhor R Stroud JC Giffin MJ Chen L Crystal structure of NFAT bound to the HIV-1 LTR tandem κB enhancer element Structure 2008 May 7 16 5 684-694
Dellisanti CD Yao Y Stroud JC Wang ZZ Chen L Structural determinants for alpha-neurotoxin sensitivity in muscle nAChR and their implications for the gating mechanism. Channels (Austin) 2007 Jul-Aug 1 4 234-237
Dellisanti CD Yao Y Stroud JC Wang ZZ Chen L Crystal structure of the extracellular domain of nACHR α1 bound to α-bungarotoxin at 1.94 Å resolution Nat Neurosci 2007 Aug 10 10 2 953-962
Wu Y Borde M Heissmeyer V Feuerer M Lapan AD Stroud JC Bates DL Guo L Han A Ziegler SF Mathis D Benoist C Chen L Rao A FOXP3 controls regulatory T cell function through cooperation with NFAT Cell 2006 July 28 126 2 375-87
Stroud JC Wu Y Bates DL Han A Nowick K Paabo S Tong H Chen L Structure of the forkhead domain of FOXP2 bound to DNA Structure 2006 Jan 14 1 159-66
Lee T Hoofnagle AN Kabuyama Y Stroud J Min X Goldsmith EJ Chen L Resing KA Ahn NG Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry Mol Cell 2004 Apr 9 14 1 43-55
Stroud JC Chen L Structure of NFAT1 bound as a dimer to DNA as a monomer J Mol Biol 2003 Dec 12 334 5 1009-22
Giffin MJ Stroud JC Bates D von Koenig KD Hardin J Chen L Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa-B element Nat Struct Biol 2003 Oct 10 10 800-6
Han A Pan F Stroud JC Youn HD Liu JO Chen L Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 Nature 2003 Apr 17 422 6933 730-4
Stroud JC Lopez-Rodriguez C Rao A Chen L Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor Nat Struct Biol 2002 Feb 9 2 90-4
Zhang LP Stroud J Eddy CA Walter CA McCarrey JR Multiple elements influence transcriptional regulation from the human testis-specific PGK2 promoter in transgenic mice Biol Reprod 1999 Jun 60 6 1329-37
Zhang LP Stroud JC Walter CA Adrian GS McCarrey JR A gene-specific promoter in transgenic mice directs testis-specific demethylation prior to transcriptional activation In vivo Biol Reprod 1998 Aug 59 2 284-92
Kumari M Stroud JC Anji A McCarrey JR Differential appearance of DNase I-hypersensitive sites correlates with differential transcription of Pgk genes during spermatogenesis in the mouse J Biol Chem 1996 Jun 14 271 24 14390-7

Book Chapters
Liu JO Chen L Pan F Stroud JC Chapter 17: NFAT and MEF2, Two Families of Calcium-dependent Transcription Regulators Gene Expression and Regulation Jun Ma Higher Education Press (Distributed by Springer Science and Business Media, LLC) Bejing P.R. China 2006

Teaching
1998-1999 Teaching Assistant University of Colorado, Department of Chemistry and Biochemistry

Presentations
West Coast Protein Crystallography Workshop Asilomar, CA Mar. 11-14, 2007 Poster YAMA: An Animation Engine for PyMOL
West Coast Protein Crystallography Workshop Asilomar, CA Mar. 20-23, 2005 Poster Fluorescence Studies of NFAT Support Crystallographic Observations
Colorado Regional Transcription Meeting Denver, CO May 5, 2001 Talk Structural Basis of Combinatorial Gene Regulation in Eukaryotic Transcription
Rocky Mountain R-AXIS Users Meeting Boulder, CO May 19-20, 2001 Talk Crystallographic Analysis of the TonEBP/TonE Complex
Keystone Symposia on NF-κB: From Bench to Bedside Keystone, CO Feb. 25-Mar. 3, 2002 Poster Structural Basis for Dimerization in the NFAT Family of Transcription Factors

Service
Journal Reviews
Journal of Cell Biology
Journal of Molecular Biology (co-reviewer with David Eisenberg)
International Conference on Intelligent Systems for Molecular Biology
Structure (co-reviewer with Lin Chen)
PNAS (co-reviewer with David Eisenberg)
Grant Reviews
National Science Foundation

Selected Open Source Software
make-na Automation of making nucleic acids by NAB.
http://structure.usc.edu/make-na
passerby A full featured password keeper.
http://passerby.sourceforge.net
extpdb A program to cut up pdb files.
http://structure.usc.edu/extpdb
dssp2pdb Converts dssp output to pdb.
http://structure.usc.edu/dssp2pdb

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